Calcium Supplementation for Prevention of Pre-eclampsia in High Risk Women: CaPE Trial

The aim of this trial is to investigate the clinical and cost-effectiveness of calcium supplementation plus usual care compared with usual care alone in women at high risk of pre-eclampsia.

HTA commissioned call to investigate the clinical and cost-effectiveness of calcium supplementation plus usual care compared with usual care alone in women at high risk of pre-eclampsia.

Background: epidemiological studies and RCTs suggest calcium may reduce risk of pre-eclampsia. However, most studies have been conducted in populations with low dietary calcium intake, so findings have not been viewed as applicable to a population with adequate calcium intake, such as in the UK. Moreover, little research has focused on impact of calcium on women at high risk of pre-eclampsia.

Chief Investigator: Dr Shireen Meher, Birmingham Women’s and Children’s NHS Foundation Trust