Recent publications involving APEC

Planned early birth versus expectant management for hypertensive disorders from 34 weeks' gestation to term

Published in Cochrane Library, May 2026

Read the paper

Timing of birth to improve outcomes in chronic or gestational hypertension: the WILL RCT

Published in NIHR Journals Library, January 2026

Read the paper

Comparison of glycosylated fibronectin versus soluble fms-like tyrosine kinase/placental growth factor ratio testing for the assessment of pre-eclampsia: protocol for a multicentre diagnostic test accuracy study

Published in BMJ Open, January 2025

Read the paper

Self-monitoring blood pressure in Pregnancy: Evaluation of health professional experiences of the BUMP trials

Published in Pregnancy Hypertension, March 2024

Alison Chisholm, Katherine L Tucker, Carole Crawford, Marcus Green, Sheila Greenfield, James Hodgkinson, Layla Lavallee, Paul Leeson, Lucy Mackillop, Christine McCourt, Jane Sandall, Hannah Wilson, Lucy C Chappell, Richard J McManus, Lisa Hinton

Read the paper

Detection and Control of Pregnancy Hypertension Using Self-Monitoring of Blood Pressure With Automated Telemonitoring: Cost Analyses of the BUMP Randomized Trials

Published in Hypertension, January 23rd 2024

Helen E. Campbell, Lucy C. Chappell, Richard J. McManus, Katherine L. Tucker, Carole Crawford, Marcus Green and Oliver Rivero-Arias

Read the paper

Using self-monitoring to detect and manage raised blood pressure and pre-eclampsia during pregnancy: the BUMP research programme and its impact

Published in Hypertension Research, December 7th 2023

Katherine L. Tucker, Lisa Hinton, Marcus Green, Lucy C. Chappell & Richard J. McManus

Read the paper

A treatment strategy with nifedipine versus labetalol for women with pregnancy hypertension: study protocol for a randomised controlled trial (Giant PANDA)

Published in September 2023

Danielle Ashworth, Cheryl Battersby, Debra Bick, Marcus Green, Pollyanna Hardy, Lisa Leighton, Laura A. Magee, Alisha Maher, Richard J. McManus, Catherine Moakes, R. Katie Morris, Catherine Nelson-Piercy, Jenie Sparkes, Oliver Rivero-Arias, Andrew Webb, Hannah Wilson, Jenny Myers, Lucy C. Chappell

Read the paper

Hypertensive disorders of pregnancy

Published in BMJ, June 2023

Pensée Wu, Marcus Green, Jenny E Myers

Read the paper

‘Nesting networks’: Women’s experiences of social network support in high-risk pregnancy care through the lens of candidacy

Published in Midwifery, May 2023

L. Hinton, C. Dumelow , J. Hodgkinson , C. Montgomery, A. Martin, C. Allen, K Tucker, M.E. Green, H. Wilson, R.J. McManus, L.C. Chappell, R. Band

Read the paper

A qualitative study of the dynamics of access to remote antenatal care through the lens of candidacy

Published in Journal of Health Services Research & Policy, 21 April 2023

Lisa Hinton, Karolina Kuberska, Francesca Dakin, Nicola Boydell , Graham Martin, Tim Draycott, Cathy Winter, Richard J McManus, Lucy Chappell , Sanhita Chakrabarti, Elizabeth Howland, Janet Willars, Mary Dixon-Woods

Read the paper

Supporting Research into pre-eclampsia – charity spotlight

Published in BMJ Vol 31 p212, April 2023

Andrew H Shennan, Dianne Garland, Marcus Green

Read the paper

Accurate surveillance of maternal deaths is an international priority

Published in BMJ 2022; 16 November 2022

Andrew H Shennan, Marcus Green, Alexandra E Ridout

Read the paper

Risk factors for pre-eclampsia in clinical practice guidelines: Comparison with the evidence

Published in BJOG, October 2022

Terteel Elawad, Georgia Scott, Jeffrey N. Bone, Helen Elwell, Cristina Escalona Lopez, Veronique Filippi, Marcus Green, Asma Khalil, Mai-Lei W. Kinshella, Hiten D. Mistry, Kelly Pickerill, Reshma Shanmugam, Joel Singer, Rosemarie Townsend, Eleni Z. Tsigas, Marianne Vidler, Marie-Laure Volvert, Peter von Dadelszen, Laura A. Magee

Read the paper

Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-2)

Published in PubMed, 22 September 2022

Alice Hurrell, Jenie Sparkes, Kate Duhig, Paul T Seed, Jenny Myers, Cheryl Battersby, Katherine Clark, Marcus Green, Rachael M Hunter, Andrew H Shennan, Lucy C Chappell, Louise Webster

Read the paper

Risk factors for pre‐eclampsia in clinical practice guidelines: comparison with the evidence

Published in BJOG: An International Journal of Obstetrics & Gynaecology, September 2022

Read the paper

Implementation of a novel shared decision-making intervention in women with chronic hypertension in pregnancy: multiple-site multiple-method investigation

Published in Pregnancy Hypertension, September 2022

Rebecca Whybrow, Jane Sandall, Joanna Girling, Heather Brown, Paul T Seed, Marcus Green, Sarah Findlay, Louise Webster, Lucy C Chappell

Read the paper

A Quality framework for remote antenatal care: qualitative study with women, healthcare professionals and system-level stakeholders

Published in the BMJ, May 2022

Lisa Hinton, Francesca H Dakin, Karolina Kuberska, Nicola Boydell, Janet Willars, Tim Draycott, Cathy Winter, Richard J McManus, Lucy C Chappell, Sanhita Chakrabarti, Elizabeth Howland, Jenny George, Brandi Leach, Mary Dixon-Woods

Read the paper

Effect of Self-monitoring of Blood Pressure on Diagnosis of Hypertension During Higher-Risk Pregnancy – The BUMP 1 Randomized Clinical Trial

Published in Journal of the American Medical Association, May 2022

Katherine L. Tucker, Sam Mort, Ly-Mee Yu, Helen Campbell, Oliver Rivero-Arias, Hannah M. Wilson, Julie Allen, Rebecca Band, Alison Chisholm, Carole Crawford, Greig Dougall, Lazarina Engonidou, Marloes Franssen, Marcus Green, Sheila Greenfield, Lisa Hinton, James Hodgkinson, Layla Lavallee, Paul Leeson, Christine McCourt, Lucy Mackillop, Jane Sandall, Mauro Santos, Lionel Tarassenko, Carmelo Velardo, Lucy Yardley, Lucy C. Chappell, Richard J. McManus

Read the paper

Effect of Self-monitoring of Blood Pressure on Blood Pressure Control in Pregnant Individuals With Chronic or Gestational Hypertension – The BUMP 2 Randomized Clinical Trial

Published in Journal of the American Medical Association, May 2022

Lucy C. Chappell, Katherine L. Tucker, Ushma Galal, Ly-Mee Yu, Helen Campbell, Oliver Rivero-Arias, Julie Allen, Rebecca Band, Alison Chisholm, Carole Crawford, MSc; Greig Dougall, Lazarina Engonidou, Marloes Franssen, Marcus Green, Sheila Greenfield, Lisa Hinton, James Hodgkinson, Layla Lavallee, Paul Leeson, Christine McCourt, Lucy Mackillop, Jane Sandall, Mauro Santos, Lionel Tarassenko, Carmelo Velardo, Hannah Wilson, Lucy Yardley, PhD; Richard J. McManus

Read the paper

Planned delivery or expectant management in pre-eclampsia: an individual participant data meta-analysis

Published in American Journal of Obstetrics and Gynaecology, 26 April 2022

Alice Beardmore-Gray, Paul T. Seed, Jessica Fleminger, Eva Zwertbroek, Thomas Bernardes, Ben W.Mol, Cheryl Battersby, Corine Koopmans, Kim Broekhuijsen,Kim Boers, Michelle Y.Owens, JimThornton, Marcus Green, Andrew H.Shennan, Henk Groen, Lucy C.Chappell

Read the paper

Two‐year follow‐up of infant and maternal outcomes after planned early delivery or expectant management for late preterm pre‐eclampsia (PHOENIX): a randomised controlled trial

Published in BJOG An International Journal of Obstetrics & Gynaecology, April 2022

Alice Beardmore-Gray, Melanie Greenland, Louise Linsell, Edmund Juszczak, Pollyanna Hardy, Anna Placzek, Rachael Hunter, Jenie Sparkes, Marcus Green, Andrew H Shennan, Neil Marlow, Lucy C Chappell

Read the paper

Postnatal health and care following hypertensive disorders in pregnancy: a prospective cohort study (BPiPP study)

Published in BMC Pregnancy and Childbirth, 22 April 2022

Danielle Ashworth, Liza Bowen, Paul T. Seed, Sophie P. Maule, Marcus Edward Green, Debra E Bick, Lucy C. Chappell

Read the paper

Paracetamol use in pregnancy — neglecting context promotes misinterpretation

Published in Nature Reviews Endocrinology, March 2022

Joseph O’Sullivan, Alexandra E. Cairns, Elena Plesca, Rebecca S. Black, Charlotte Frise, Manu Vatish and Ana Sofia Cerdeira

Read the paper

Which antihypertensive treatment is better for mild to moderate hypertension in pregnancy?

Published in BMJ 2022, 18 January 2022

Danielle Ashworth, Cheryl Battersby, Marcus Green, Pollyanna Hardy, Richard J McManus, Catherine Cluver, Lucy C Chappell

Read the paper

Factors influencing perinatal outcomes in women with preterm pre-eclampsia: A secondary analysis of the PHOENIX trial

Published in Pregnancy Hypertension, 26 December 2021

Jessica Fleminger, Kate Duhig, Paul T Seed, Peter Brocklehurst, Marcus Green, Edmund Juszczak, Neil Marlow, Andrew H Shennan, Lucy C Chappell

Read the paper

Planned delivery to improve postpartum cardiac function in women with preterm pre-eclampsia: the PHOEBE mechanisms of action study within the PHOENIX RCT

Published in Efficacy and Mechanism Evaluation, 21 September 2021

Fergus P McCarthy, Jamie O’Driscoll, Paul Seed, Anna Brockbank, Alice Cox, Carolyn Gill, Marcus Green, Mike Marber, Lucilla Poston, Anna Placzek, Andrew Shennan, Jenie Sparkes, Paul Leeson, Basky Thilaganathan, Lucy C Chappell

Read the paper

The impact of pre-eclampsia definitions on the identification of adverse outcome risk in hypertensive pregnancy – analyses from the CHIPS trial (Control of Hypertension in Pregnancy Study)

Published in BJOG: An International Journal of Obstetrics and Gynaecology, November 2020

L A Magee, J Singer, T Lee, E Rey, E Asztalo, E Hutton M Helewa, A G Logan, W Ganzevoort, R Welch, J G Thornton, M L Woo Kinshella, M Green, E Tsigas, P von Dadelszen

Read the paper

Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis.

Published in Health Technology Assessment, 24 December 2020

Allotey J, Snell KI, Smuk M, Hooper R, Chan CL, Ahmed A, Chappell LC, von Dadelszen P, Dodds J, Green M, Kenny L, Khalil A, Khan KS, Mol BW, Myers J, Poston L, Thilaganathan B, Staff AC, Smith GC, Ganzevoort W, Laivuori H, Odibo AO, Ramírez JA, Kingdom J, Daskalakis G, Farrar D, Baschat AA, Seed PT, Prefumo F, da Silva Costa F, Groen H, Audibert F, Masse J, Skråstad RB, Salvesen KÅ, Haavaldsen C, Nagata C, Rumbold AR, Heinonen S, Askie LM, Smits LJ, Vinter CA, Magnus PM, Eero K, Villa PM, Jenum AK, Andersen LB, Norman JE, Ohkuchi A, Eskild A, Bhattacharya S, McAuliffe FM, Galindo A, Herraiz I, Carbillon L, Klipstein-Grobusch K, Yeo S, Teede HJ, Browne JL, Moons KG, Riley RD, Thangaratinam S.

Read the paper (PMID: 33336645; PMCID: PMC7780127)

PHOENIX Study Group. Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial

Published in The Lancet, 28 September 2019

Chappell LC, Brocklehurst P, Green ME, Hunter R, Hardy P, Juszczak E, Linsell L, Chiocchia V, Greenland M, Placzek A, Townend J, Marlow N, Sandall J, Shennan A

Read the paper (PMID: 31472930; PMCID: PMC6892281)

Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)

Published in Trials, 18 January 2019

Chappell LC, Green M, Marlow N, Sandall J, Hunter R, Robson S, Bowler U, Chiocchia V, Hardy P, Juszczak E, Linsell L, Placzek A, Brocklehurst P, Shennan A.

Read the paper (PMID: 30691508; PMCID: PMC6350286)

Reducing maternal deaths from hypertensive disorders: learning from confidential inquiries

Published in the British Medical Journal (BMJ), 5 February 2019

Conti-Ramsden F, Knight M, Green M, Shennan AH, Chappell LC.

Read the paper (PMID: 30723108)

Maternal deaths in the UK: pre-eclampsia deaths are avoidable

Published in The Lancet, 11 February 2017

Shennan AH, Green M, Chappell LC.

Read the paper (PMID: 28195043)

Aspirin should be targeted to those who need it

Published in BJOG, 5 September 2020

Green M, Shennan A.

Read the paper (PMID: 32892486)

IPPIC Network. Prediction of pre-eclampsia: review of reviews

Published in Ultrasound Obstet Gynecol, July 2019

Townsend R, Khalil A, Premakumar Y, Allotey J, Snell KIE, Chan C, Chappell LC, Hooper R, Green M, Mol BW, Thilaganathan B, Thangaratinam S

Read the paper (PMID: 30267475)

Why is the search for pre-eclampsia prevention so elusive?

Published in The BMJ, 12 September 2018

Myers JE, Green M, Chappell LC.

Read the paper (PMID: 30209065)

IPPIC Collaborative Network. External validation, update and development of prediction models for pre-eclampsia using an Individual Participant Data (IPD) meta-analysis: The International Prediction of Pregnancy Complication Network (IPPIC pre-eclampsia)

Published in Diagnostic and Prognostic Research, 3 October 2017

Allotey J, Snell KIE, Chan C, Hooper R, Dodds J, Rogozinska E, Khan KS, Poston L, Kenny L, Myers J, Thilaganathan B, Chappell L, Mol BW, Von Dadelszen P, Ahmed A, Green M, Poon L, Khalil A, Moons KGM, Riley RD, Thangaratinam S

Read the paper (PMID: 31093545; PMCID: PMC6460674)

IPPIC Collaborative Network. External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis

Published in BMC Medicine, 2 November 2020

Snell KIE, Allotey J, Smuk M, Hooper R, Chan C, Ahmed A, Chappell LC, Von Dadelszen P, Green M, Kenny L, Khalil A, Khan KS, Mol BW, Myers J, Poston L, Thilaganathan B, Staff AC, Smith GCS, Ganzevoort W, Laivuori H, Odibo AO, Arenas Ramírez J, Kingdom J, Daskalakis G, Farrar D, Baschat AA, Seed PT, Prefumo F, da Silva Costa F, Groen H, Audibert F, Masse J, Skråstad RB, Salvesen KÅ, Haavaldsen C, Nagata C, Rumbold AR, Heinonen S, Askie LM, Smits LJM, Vinter CA, Magnus P, Eero K, Villa PM, Jenum AK, Andersen LB, Norman JE, Ohkuchi A, Eskild A, Bhattacharya S, McAuliffe FM, Galindo A, Herraiz I, Carbillon L, Klipstein-Grobusch K, Yeo SA, Browne JL, Moons KGM, Riley RD, Thangaratinam S

Read the paper (PMID: 33131506; PMCID: PMC7604970.)

Research priorities for pregnancy hypertension: a UK priority setting partnership with the James Lind Alliance

Published in BMJ Open, 14 July 2020

Ho A, Webster L, Bowen L, Creighton F, Findlay S, Gale C, Green M, Gronlund T, Magee LA, McManus RJ, Mistry HD, Singleton G, Thornton J, Whybrow R, Chappell L.

Read the paper

Blood pressure monitoring in high-risk pregnancy to improve the detection and monitoring of hypertension (the BUMP 1 and 2 trials): protocol for two linked randomised controlled trials

Published in BMJ Open, 23 January 2020

Dougall G, Franssen M, Tucker KL, Yu LM, Hinton L, Rivero-Arias O, Abel L, Allen J, Band RJ, Chisholm A, Crawford C, Green M, Greenfield S, Hodgkinson J, Leeson P, McCourt C, MacKillop L, Nickless A, Sandall J, Santos M, Tarassenko L, Velardo C, Wilson H, Yardley L, Chappell L, McManus RJ.