PARROT-2 Follow on study assesses impact of PlGF tests

Repeat placental growth factor-based testing for women with suspected preterm pre-eclampsia: the PARROT-2 Trial

Researchers at Kings College London are in the process of conducting a follow on study to PARROT, PARROT-2.

“PlGF-based testing has been demonstrated to be useful in ruling out a diagnosis of pre-eclampsia. In the PARROT trial, we did a single PlGF test in women who came to the maternity unit with suspected pre-eclampsia. We found that in women who had the test result, it halved the time it took to diagnose pre-eclampsia and significantly lowered the chance of serious complications for women. However, we do not yet know who needs repeat PlGF tests, or how often we should them. We are trying to find out which women and babies benefit and how much this would cost the NHS (or whether it would save money). We know that pre-eclampsia can be very serious for the woman and the baby, with some babies dying as a result, and we want to improve this. “

“We are doing a follow-on study called the PARROT-2 trial. In this study, we are comparing what happens in women who have repeat PlGF-based testing with those who don’t, to see if this has any impact on complications for women or their babies (such as stillbirth, neonatal death, or the baby needing to be admitted to the neonatal unit). We are aiming to conduct this study in at least 15 maternity units across the UK and ask at least 1280 women to take part.”

If you would like any further information, please contact Dr Alice Hurrell, the Trial Coordinator on alice.hurrell@kcl.ac.uk .